Gamma interferon loaded onto albumin nanoparticles: in vitro and in vivo activities against Brucella abortus.

Brucella abortus Activities against Nanoparticles: In Vitro and In Vivo Gamma Interferon Loaded onto Albumin

Immunogencity of HSA-L7/L12 (Brucella abortus Ribosomal Protein) in an Animal Model

Background: The immunogenic Brucella abortus ribosomal protein L7/L12 is a promising candidate antigen for the development of subunit vaccines against brucellosis. Objective: This study was aimed to evaluate the protection of recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein in Balb/c mice. Methods: The amplified L7/L12 gene was cloned in pYHSA5 vector, pYHSA5-L7/L12 construct was tra...

Hydrophobic gentamicin-loaded nanoparticles are effective against Brucella melitensis infection in mice.

The clinical management of human brucellosis is still challenging and demands in vitro active antibiotics capable of targeting the pathogen-harboring intracellular compartments. A sustained release of the antibiotic at the site of infection would make it possible to reduce the number of required doses and thus the treatment-associated toxicity. In this study, a hydrophobically modified gentamic...

The effect of some of the Iranian medicinal plants on Brucella Abortus on In-vitro and In-vivo

Introduction & Aim: The ethanol and aqueous extracts of Alhagi camelorum Fisch. (Fabaceae) whole plant, Scrophularia desertii Del. (Scrophulariaceae) whole plant and ethanol extracts of Echinophora platyloba DC. (Apiaceae) whole plant, Teucrium polium L. (Lamiaceae) whole plant and Berberis integerrima Bunge root b...

Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice.

Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not fur...